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基于生理学的PK-sim5模型:介绍和演示

PK-Sim 5 for Physiology Based PK modelling: Introduction and Demonstration
课程网址: http://videolectures.net/mdo2014_kanacher_pk_modelling/  
主讲教师: Tobias Kanacher
开课单位: 拜耳技术服务有限公司
开课时间: 2014-07-21
课程语种: 英语
中文简介:
基于生理学的药代动力学模型(PBPK)基于大量的生理学知识描述药物在人体内的吸附、分布、代谢和排泄。在PBPK模型的结构中明确地提供了具体的生理信息,例如血流速度或相对组织特异性基因表达。大多数其他参数可以根据正在研究的化合物的物理化学性质来计算,例如亲油性和分子量。PBPK模型尤其可用于机械研究药物动力学的不同过程。使用软件PK-Sim,我们在这里介绍PBPK建模,它允许用户独立地实现第一个模型模型。
课程简介: Physiology-based pharmacokinetic models (PBPK) describe adsorption, distribution, metabolisation and excretion of drugs in the human body based on a large amount of prior physiological knowledge. Specific physiological information quantifying for example blood flow rates or relative tissue-specific gene-expression is explicitly provided in the structure of PBPK models. Most other parameters can be calculated from the physicochemical properties of the compound which is under investigation such as the lipophilicity and the molecular weight. PBPK models can in particular be used to mechanistically investigate the different processes underlying drug pharmacokinetics. Using the software PK-Sim, we here provide an introduction to PBPK modelling which allows the user to independently implement a first model model.
关 键 词: 生理学; 药物; 药代动力学模型
课程来源: 视频讲座网
入库时间: 2020-11-11
数据采集: 2020-11-11:yxd
最后编审: 2020-11-11:yxd
阅读次数: 494